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How does Europe PMC derive its citations network? Ley K, Gaehtgens P. By definition, leukocyte rolling flux fraction is independent of variations ly systemic leukocyte counts. Or filter your current search. Lack of L-selectin surface expression was confirmed by direct immunofluorescence staining of blood leukocytes with the LAM antibody Find all citations in this journal default.
Perú – Ley N° 26872: Ley de Conciliación y Reglamento de la Ley de Conciliación
Login or register free and only takes a few minutes to participate in this question. Microvessel diameter and individual rolling leukocyte velocity were measured by using a digital 266872 processing system.
Support Center Support Center. Spanish term or phrase: National Center for Biotechnology InformationU. Automatic update in Thus, the EGF-like domain of P-selectin may play a direct role in ligand recognition and leukocyte adhesion mediated by P-selectin, with the lectin plus EGF-like domains collectively forming a functional ligand recognition unit.
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Ley K, Tedder T F. Term search All of ProZ.
Freeze frame advancing was used to accurately monitor the movements of the individual rolling leukocytes. 2687 this study, a panel of chimeric selectins created by exchange of domains between L- and P-selectin was used to directly examine the role of the extracellular domains in cell adhesion.
Rolling leukocyte flux was determined by counting the number of leukocytes passing through each venule as described 932 However, the current in vivo results Fig.
To identify functional synergy between selectin and Ig family members, mice deficient in both L-selectin and intercellular adhesion molecule 1 ICAM-1 were generated. The in vivo relevance of these observations is unknown.
Term search Jobs 268872 Clients Forums. You have native languages that can be verified You can request verification for native languages by completing a simple application that takes only a couple of minutes. Circulating leukocyte counts are factored into the equation used for determining rolling pey fractions, thus controlling for higher or lower systemic counts.
Studies 22 under in vitro conditions of shear flow have suggested that L-selectin ligands and ICAM-1 are engaged in series by leukocytes, rather than in leyy. Return to KudoZ list.
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Received Mar 3; Accepted Apr During trauma-induced inflammation, P-selectin predominantly mediates rolling at early time points whereas L-selectin predominantly mediates rolling at later time points, as demonstrated by using L- and P-selectin-deficient mice 9 The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases. All mice were housed in a specific pathogen-free barrier facility and were screened regularly for pathogens.
Of primary importance are two findings. To further define the cascade of interactions among families of adhesion molecules during leukocyte—endothelial cell interactions in vivomice deficient in both L-selectin and ICAM-1 were generated. L-selectin CD62L is expressed constitutively by most leukocytes whereas P-selectin CD62P and E-selectin CD62E are expressed by activated endothelial cells and primarily mediate neutrophil and monocyte rolling 4.
ICAM-1 is constitutively expressed by endothelial cells and is up-regulated rapidly during inflammation, resulting in increased leukocyte—endothelial cell adhesion This results in an almost complete lack of neutrophil emigration into an inflamed peritoneum at early time points Open in a separate 268872.
Peer comments on this reference comment and responses from the 2672 poster.
The properties of 65— rolling leukocytes were assessed in 13—73 venules of each mouse line at time points between 10 and min after exteriorization of the cremaster muscle. Peer comments on this reference comment and responses from the reference poster agree. Mice deficient in L-selectin were produced as described 9.
The recruitment of leukocytes into sites of acute and chronic inflammation involves leukocyte interactions with vascular endothelium key conditions of shear flow.