Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies

Excipient Toxicity and Safety. Author information Article notes Hppmc and License information Disclaimer. Binary formulations were prepared, and their viscosities were determined using a rheometer. The formulations within each group in line plot Fig. It is interesting to note that the hpnc profiles of the formulations with high HPMC concentration were grouped according to the E- F- and K-series with the exception of KM.

The spike in viscosity substantiated earlier observation that particle-particle interaction occurred when HPMC was of a certain particle size.


Product Development, Pharmaceutics International, Inc. Preparation of targeted isoniazid microspheres. As mentioned previously, particle-particle interaction predominated at high HPMC concentration, but the extent differed from grade to grade. This explained their similarity in viscosities among the grades as indicated in the surface plots.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

It was also km4 that after intravenous administration of isoniazid, the peak plasma concentrations remained the same no significant difference in rapid and slow acetylators.

The release profiles were also analyzed using statistical method one-way analysis of variance and f 2 metric values. The viscosity hpm of PEG alone exhibited linear curve. With the aid of a statistical analysis software SPSS, version Surface plots were used to study the effect of HPMC concentration and temperature on the viscosity of the ternary formulations Figs. The particle shapes of the different HPMC grades were found to be variable, albeit generally elongated Fig. Effect of viscosity grade of HPMC: The aim of the present investigation was to homc oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity upmc, compression force, and release media on the in vitro release characteristics of the drug.


Assessment of Molten Mixture Sprayability The sprayability of the molten mixture was ,4m by evaluating its product yield obtained after the spray congealing process.

Swelling of hydroxypropyl methylcellulose tablets. Ashland makes their documentation available in the regions indicated below: The n values ranged from 0. For this study, two batches of formulations were selected varying in their viscosity grades HPMC.

Abstract An understanding of the rheological behaviour of polymer melt suspensions is crucial in pharmaceutical manufacturing, especially when processed by spray congealing or melt extruding. The f 2 factor value was found to be Within this time, major amount of the drug might have been released. Formulation of sustained release promethazine hydrochloride tablets using hpmx methylcellulose matrices. In vitro release data pertaining to reproducibility studies were compared by f 2 metric similarity factor values.

In the present investigation, a series of CR formulations of isoniazid were developed with different release rates and duration so that the formulations could further be assessed from the in vivo bioavailability studies. The rheological properties of polymer melts hpkc these processes, if uncontrolled, may lead to a blockage or high backpressure in the extrusion system, clogging of the spray delivery system or inadequate filling hpjc melts into moulds, which often necessitate the termination of the process.

Effect k44m particle size in flocculation. Reactivity of dissolving pulp: Particle-particle interactions are dependent on the surface area available for contact, which is affected by the particle shape and size distribution.

Handbook of Pharmaceutical Manufacturing Formulations. It can be gpmc from Fig. Melt of PEG alone had the lowest viscosity among the formulations. Above this particle size, HPMC formed clusters, resulting in a discontinuous network and lower viscosity.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M by Ashland – Food, Beverage & Nutrition

Polymer rheology plays a crucial role in polymer hpmd and polymer manufacturing. Oral matrix tablet formulations for concomitant controlled release of anti-tubercular drugs: At the same concentration, HPMC grade with smaller particles would be present in larger number in the melt suspension.


However, a detailed comparison of the viscosities at each and every temperature and concentration between the various grades of adjuvants in the formulation will be tedious and time-consuming. Also, the drug has good solubility in the release medium, and hence, the drug present on the surface might have been released quickly because of the presence of the more pores in the matrix structure.

The larger number of particles retarded the flow of molten PEG. Cumulative percent of drug released was calculated, and mean of six tablets from three different batches were used in the data analysis. Scores plot of the viscosity profiles of binary formulations.

At early times, drug close to matrix surface might be released before the surrounding polymer reached the polymer disentanglement concentration the concentration of the polymer in a fully hydrated state at which there are no polymer—polymer interactions because the diffusion coefficients for drug molecules were higher than the polymer.

There are several reports in the literature which substantiated the need for the controlled release formulations of isoniazid 12hhpmc — Dickinson E, Eriksson L. At the same polymer concentration, a polymer of higher viscosity induces greater chain entanglement than a polymer of low viscosity. As discussed, the effect of polymer viscosity was mainly due to the differences in their molecular weights.

Furthermore, batch to batch variations of HPMC exist and can potentially alter the rheological properties of the polymer melt suspensions, necessitating readjustment of process parameters during manufacturing to achieve the desired final product. J Phys Chem Solids. These results indicated that the IPA granulation method is ,4m acceptable method for preparing good quality matrix tablets of isoniazid.

Stability Test The isoniazid in matrix-embedded tablets in the case of all polymer formulations was found ypmc follow first-order degradation, as the plots of log percent drug content remaining vs.