Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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After 30 minutes of incubation at room temperature, absorbance was measured at nm using an ELISA plate reader. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. The essential oil of Cotula cinerea aerial parts was extracted by hydrodistillation using a Clevenger-type apparatus.

Cotula is a genus of flowering plant in the sunflower family. However, the minor compounds could also be of crucial importance; all the phytochemicals could synergistically act and enhance the observed activity [ 14 ].

The sections possess different basic chromosome numbers:. Introduction Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ].

Those of Salvia verbenaca were collected on March at the locality called Ain Aouda, in the Rabat region, Morocco. These plants are widely used in the Moroccan traditional folk medicine. In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts.

Moreover, a molecule could have an effect on one type of tumor and not on others. The concentrations that inhibit half of the cell population IC 50 were obtained by modeling the percentage of cytotoxicity versus concentration of extracts.

Cotula — Wikipédia

Retrieved 24 August The hexane, ethyl acetate, and n -butanol extraction yields were, respectively, 1. Levyns Cotula elongata B. However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca. This study is expected to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further investigations on other types of cancer cell lines.

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Cotula is the largest genus found in the Southern Hemisphere of the tribe Anthemideae. Exploring alternative sources of new antitumor agents with specific targets is thus imperative and of great and crucial importance. The results of this study showed thus that Cotula cinerea essential oil and hexane extract showed significant cytotoxic effects against RD and Vero cell lines, respectively, and could be considered as novel source of antitumor agents.

Flavonoids from Cotula cinerea Del – Semantic Scholar

A preliminary phytochemical screening of the Cotula cinerea and Salvia verbenaca extracts showed the presence of polyphenols such as flavonoids and other secondary metabolites. The evaluation of cell viability has been achieved through the use of MTT 3- 4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide assay.

The enumeration of cells was made using Malassez cell count.

View at Google Scholar F. The extraction was achieved during six hours and the obtained oil yield 0.

Cotula socialis Hilliard Cotula sororia DC. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital. Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs. Topics Discussed cotulla This Paper.

Oils, Volatile Search for additional papers on this topic. On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with the lowest IC 50 value The biological activity of C. Salvia verbenaca is a Mediterranean plant currently belonging to the Lamiaceae family. The noticed differences in the observed cytotoxicity of the investigated mixtures could obviously be due to the phytochemical composition of each extract. Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against RD cell line by MTT assay.


Views Read Edit View history. The maceration process was repeated twice during 24 h each in order to achieve an exhaustive extraction. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects Nevertheless, the Cotula cinerea essential oil can act through various mechanisms.

From Wikipedia, the free encyclopedia. In other projects Wikimedia Commons Wikispecies. Huile essentielle de Santolina africana Jord. These compounds could explain the cytotoxic effect of this extract on RD tumor cell line. A potent cytotoxicity was thus observed for the Cotula cinerea hexane extract which inhibited the growth of RD cell line at the lowest IC 50 value Subscribe to Table of Contents Alerts.

Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy. This genus was first mentioned by Carl Linnaeuswho described four species in his first edition of Species Plantarum. The absorbance of the formazan will then be determined by spectrophotometry at nm. Mouzdahir A Huile essentielle de Santolina africana Jord. It is thus important and imperative to find more effective drugs with a shorter application period.

Lloyd has proposed that the five species from Australia and New Guinea are distinctive enough from the other species from the section Leptinella to be brought under a new section with the proposed name Oligoleima type species C.

Flavonoids from Cotula cinerea Del

The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil. Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7].

However, and despite all the progress made, the cancer treatment remains a challenging task for both the patients and the medical staff.